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Abstract #1161

Tracking tissue oxygenation status and response using Diffusion-Weighted functional MRI

Zhongwei Zhang 1 , Rami R Hallac 1 , Qing Yuan 1 , Peter Peschke 2 , and Ralph P Mason 1

1 Department of Radiology, The University of Texas Southwestern Medical Center, Dallas, TX, United States, 2 Clinical Cooperation Unit Radiation Oncology, German Cancer Research Center, Heidelberg, Germany

The diffusion-sensitized fMRI (DfMRI) has the potential to provide noninvasive measurements of tissue oxygenation using oxygen as an endogenous paramagnetic contrast agent, in this study, we compared DfMRI response with BOLD, TOLD responses to gas breathing challenge under different baseline pO2 level. The feasibility of DfMRI for tracking tissue oxygenation status was evaluated. Our study showed that DfMRI is a powerful tool to tracking tissue oxygenation status and it can also provide the extent of response when combining baseline pO2 measurement.

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