Abstract #1153
1 Tesla Bench-top MRI of a Mouse Model of Colorectal Carcinoma Metastasis in the Liver: Comparison with 9.4 Tesla
Rajiv Ramasawmy* 1,2 , Thomas Roberts* 1,3 , Bernard Siow 1 , Sean Peter Johnson 1,2 , Jack Anthony Wells 1 , Alan Bainbridge 4 , Rosamund Barbara Pedley 2 , Mark Francis Lythgoe 1 , and Simon Walker-Samuel 1
1
Centre for Advanced Biomedical Imaging,
University College London, London, Greater London,
United Kingdom,
2
Cancer
Institute, University College London, London, Greater
London, United Kingdom,
3
Centre
for Mathematics and Physics in the Life Sciences and
Experimental Biology, University College London, London,
Greater London, United Kingdom,
4
Department
of Medical Physics, University College London, London,
Greater London, United Kingdom
Low-field pre-clinical MRI scanners offer economical
imaging of small animal models of cancer, although
whether they provide sufficient signal-to-noise for the
detection of tumours within reasonable imaging times is
currently unknown. In this study, tumour and liver
volumes were measured in a mouse model of liver
metastasis using a 1T bench-top MRI system and a 9.4T
scanner. Volumetric comparison was performed, alongside
signal-to-noise characterisation and contrast assessment
between tumour and liver. T1 and T2 mapping is also
reported. Volumetric analysis of livers and tumours
showed good correspondence, suggesting that bench-top
MRI scanners potentially offer a cost-effective platform
for accurately monitoring deep-seated tumour models and
liver diseases.
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