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Abstract #1151

Redox state imaging in a mouse model of aggressive prostate cancer

Alan B McMillan 1 , Bilal Bin-Hafeez 2 , Ajit K Verma 2 , Weixiong Zhong 3 , Terry D Oberley 3 , and Luksana Chaiswing 3

1 Radiology, University of Wisconsin, Madison, Wisconsin, United States, 2 Human Oncology, University of Wisconsin, Madison, Wisconsin, United States, 3 Pathology and Laboratory Medicine, University of Wisconsin, Madison, Wisconsin, United States

The use of stable free radical contrast agents (nitroxides) has been demonstrated in MRI and electron paramagnetic resonance imaging (EPRI). The agent 4-Hydroxy-2,2,6,6-tetramethylpiperidine-N-oxyl (TEMPOL) is a superoxide dismutase mimetic that also shortens longitudinal relaxation time (T1). After intravenous administration, the temporal rate of T1-weighted signal normalization is increased in tissues that are more oxidizing. The redox status (balance of oxidizing and reducing species) is important in cancer progression, where cancer aggressiveness is related to increased tissue oxidation. The purpose of this work is to investigate the feasibility of measuring TEMPOL signal dynamics in mouse models of prostate cancer.

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