Abstract #1151
Redox state imaging in a mouse model of aggressive prostate cancer
Alan B McMillan 1 , Bilal Bin-Hafeez 2 , Ajit K Verma 2 , Weixiong Zhong 3 , Terry D Oberley 3 , and Luksana Chaiswing 3
1
Radiology, University of Wisconsin, Madison,
Wisconsin, United States,
2
Human
Oncology, University of Wisconsin, Madison, Wisconsin,
United States,
3
Pathology
and Laboratory Medicine, University of Wisconsin,
Madison, Wisconsin, United States
The use of stable free radical contrast agents
(nitroxides) has been demonstrated in MRI and electron
paramagnetic resonance imaging (EPRI). The agent
4-Hydroxy-2,2,6,6-tetramethylpiperidine-N-oxyl (TEMPOL)
is a superoxide dismutase mimetic that also shortens
longitudinal relaxation time (T1). After intravenous
administration, the temporal rate of T1-weighted signal
normalization is increased in tissues that are more
oxidizing. The redox status (balance of oxidizing and
reducing species) is important in cancer progression,
where cancer aggressiveness is related to increased
tissue oxidation. The purpose of this work is to
investigate the feasibility of measuring TEMPOL signal
dynamics in mouse models of prostate cancer.
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