Abstract #1147
Effect of c-Myc Expression on Cellular-Interstitial Water Exchange Kinetics: Conditional Transgenic Mouse Breast Cancer Model
Ramesh Paudyal 1 , Sergey Magnitsky 2 , Steve Pickup 3 , Lewis A. Chodosh 4 , Charles Springer 5 , and Jerry D. Glickson 3
1
Yerkes Imaging Center, Yerkes Regional
Primate Research Center, Emory University, Atlanta, GA,
United States,
2
Radiology,
USCF, CA, United States,
3
Radiology,
University of Pennsylvania, Philadelphia, PA, United
States,
4
Department
of Cancer Biology, University of Pennsylvania,
Philadelphia, PA, United States,
5
Advanced
Imaging Research Center, Oregon Health & Science
University, OR, United States
In this study, we evaluate the effect on
cellular-interstitial water exchange in Transgenic
MTB/TOM mice DCE-MRI data, which conditionally express
the human oncogene c-myc in mammary glands in response
to doxycycline (dox) treatment, using Shutter Speed
Model (SSM). The data were measured with dox and 4 days
after withdrawal of dox. Herein, we observed a
significant decrease in Ktrans and ti after a removal of
dox. Changes in Ktrans and ti might serve as surrogate
biomarkers in breast cancer study.
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