Abstract #1145
Neurochemical profile differentiation of glioma induced by cancer stem cells expressing WIF1: a 1 H-MRS longitudinal study at 14.1T
Marta Lai 1 , Cristina Cudalbu 2 , Bernard Lanz 1,3 , Irene Vassallo 4 , Marie-France Hamou 4 , Monika Hegi 4 , and Rolf Gruetter 2,5
1
Laboratory of Functional and Metabolic
Imaging (LIFMET), Ecole Polytechnique Fdrale de
Lausanne, Lausanne, Switzerland,
2
Centre
dImagerie Biomedicale, Ecole Polytechnique Fdrale de
Lausanne, Lausanne, Switzerland,
3
Department
of Radiology, University of Lausanne, Lausanne,
Switzerland,
4
Laboratory
of Brain Tumor Biology and Genetics, Department of
Neurosurgery, Lausanne University Hospital, Lausanne,
Switzerland,
5
Departments
of Radiology, University of Lausanne and Geneva,
Switzerland
WIF1 gene has been recently identified as a tumor
suppressor gene in glioblastoma. Human glioma stem cells
have been genetically modified for the expression of the
WIF1 gene, they were injected intracranially in NUDE
mice for
1
H
MRS analysis and compared with a group of mice injected
with the analogue cell line without modifications.
Quantification of
1
H
MRS spectra acquired longitudinally throughout the tumor
development showed distinct metabolic features in the
two groups of mice which correlate with a less
aggressive phenotype for glioma stem cells expressing
WIF1.
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