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Abstract #1135

Nitroxoline induces apoptosis and slows glioma growth in vivo

Jelena Lazovic 1 , Lea Guo 1 , Jonathan Nakashima 2 , and Whitney Pope 3

1 Radiology, University of California, Los Angeles, California, United States, 2 Molecular and Medical Pharmacology, University of California, Los Angeles, California, United States, 3 University of California, Los Angeles, California, United States

Chemotherapeutic potential of FDA approved small molecule nitroxoline was evaluated in preclinical Pten/Kras glioma mouse model. The glioma volume before and after nitroxoline therapy was measured using T2-weighted MR images. Apparent diffusion coefficient and T2-values were quantified in order to determine if they can be used to predict treatment response. A significant reduction in glioma growth at 7 and 14 days was accompanied with significant increase in ADC values, while there was no change in T2-values. Histological examination and TUNEL staining revealed significantly more TUNEL-labeled cells in nitroxoline treated mice, implicating nitroxoline is potent at inducing apoptosis in this model.

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