Abstract #1133
Gallium maltolate inhibits angiogenesis in brain tumor xenograft model
Kimberly R Pechman 1 , Andrew Lozen 1 , Christopher R Chitambar 2 , and Kathleen M Schmainda 3
1
Neurosurgery, Medical College of Wisconsin,
Milwaukee, WI, United States,
2
Medicine,
Medical College of Wisconsin, Milwaukee, WI, United
States,
3
Radiology
& Biophysics, Medical College of Wisconsin, Milwaukee,
WI, United States
Malignant brain tumors are difficult to treat and
patient survival is dismal. MRI measures of enhancing
tumor volume have proven unreliable since decreases in
enhancement may be independent of biologic effect. The
purpose of this study was to investigate a novel
therapy, gallium maltolate, for brain tumors using the
U87 xenograft model. In this study we used steady state
and DSC-MRI to measure tumor blood volume and flow. The
studies, demonstrate that the novel gallium maltolate
therapy inhibits brain tumor angiogenesis.
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