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Abstract #1133

Gallium maltolate inhibits angiogenesis in brain tumor xenograft model

Kimberly R Pechman 1 , Andrew Lozen 1 , Christopher R Chitambar 2 , and Kathleen M Schmainda 3

1 Neurosurgery, Medical College of Wisconsin, Milwaukee, WI, United States, 2 Medicine, Medical College of Wisconsin, Milwaukee, WI, United States, 3 Radiology & Biophysics, Medical College of Wisconsin, Milwaukee, WI, United States

Malignant brain tumors are difficult to treat and patient survival is dismal. MRI measures of enhancing tumor volume have proven unreliable since decreases in enhancement may be independent of biologic effect. The purpose of this study was to investigate a novel therapy, gallium maltolate, for brain tumors using the U87 xenograft model. In this study we used steady state and DSC-MRI to measure tumor blood volume and flow. The studies, demonstrate that the novel gallium maltolate therapy inhibits brain tumor angiogenesis.

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