Abstract #1122
Assessment of tumor physiological changes following hypo-fractionated SBRT using multi-parametric MRI
Heling Zhou 1 , Rebecca Denney 1 , Zhang Zhang 2 , Debabrata Saha 2 , and Ralph P Mason 1
1
Radiology, University of Texas Southwestern
Medical Center, Dallas, TX, United States,
2
Radiation
Oncology, University of Texas Southwestern Medical
Center, Dallas, TX, United States
Tumor hypoxia is an important biomarker related to tumor
treatment response, but non-invasive measurements in
vivo require further development, application and
validation. We have applied oxygen enhanced MRI together
with DCE MRI to explore the longitudinal effects of
hypofractionated stereotactic body radiation therapy on
tumor re-oxygenation and development. BOLD and TOLD
responses to oxygen breathing challenge were found to
decrease following radiation. Quantitative T
2
*
also showed the same trend, whereas quantitative DCE
parameters (v
e
and
K
trans
) remained unchanged. These
observations suggest potential noninvasive assessment of
tumor re-oxygenation for treatment planning.
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