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Abstract #1105

Error Quantification in Relaxivity Rate Change (∆R1) Due to Systematic Errors in Dynamic Contrast Enhanced MR Studies

Hassan Bagher-Ebadian 1,2 , Siamak P. Nejad-Davarani 3,4 , James R Ewing 2,3 , and Hamid Soltanian-Zadeh 1,5

1 Radiology, Henry Ford Hospital, Detroit, MI, United States, 2 Physics, Oakland University, Rochester, MI, United States, 3 Neurology, Henry Ford Hospital, Detroit, MI, United States, 4 Biomedical Engineering, University of Michigan, Ann Arbor, MI, United States, 5 CIPCE, ECE Dept., University of Tehran, Tehran, Iran

In Dynamic Contrast Enhanced (DCE) MR studies, assessment of systematic errors propagated in longitudinal relaxation rate change, ∆R1(t), is important since errors in ∆R1(t) profile, biases permeability parameters estimated in DCE-MR-Pharmacokinetic analysis. Herein, we asses and quantify the biasing of ∆R1(t) profile at different enhancement-ratios in the DCE-T1 (3D-Spoiled-Gradient-Echo) experiment. Biasing arises from the deviation of actual-to-nominal dynamic-flip-angle and also the systematic error in estimating of resting T1 in Variable-Flip-Angle experiments prior to the contrast agent administration. Results imply that ∆R1(t), regardless of its enhancement ratio, is more susceptible to the underestimations of T1 and dynamic-flip-angel compared to their overestimations

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