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Abstract #1102

ASSESSING THE EFFECTS OF DECREASING TEMPORAL RESOLUTION ON PHARMACOKINETIC ANALYSIS USING A LOCAL VASCULAR INPUT FINCTION

Hatef Mehrabian 1 , Masoom A. Haider 2 , and Anne L. Martel 1

1 Medical Biophysics, University of Toronto, Toronto, Ontario, Canada, 2 Medical Imaging, Sunnybrook Health Sciences Centre, Toronto, Ontario, Canada

Pharmacokinetic (PK) analysis of tumor DCE-MRI provides information about its vasculature. Such analysis requires an AIF, which has a narrow temporal profile, and its measurement requires data with high temporal resolution (resulting in low spatial resolution images). This paper investigates possibility of using a local vascular input function (VIF) that has a wider temporal profile and can be measured in low temporal resolution datasets, in PK analysis and shows VIF-based PK parameters are less sensitive to low temporal resolution compared to AIF-based parameters. Lowering temporal resolution enables imaging with high spatial resolution which improves both VIF calculation and PK analysis.

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