Abstract #1092
Evidence of intra-patient and inter-patient heterogeneity in the microvasular characteristics of colorectal cancer liver metastases
Laura Horsley 1 , Neil Thacker 2 , Ross Little 3 , Yvonne Watson 3 , Sue Cheung 3 , Geoff Parker 3 , Gordon Jayson 1 , and Alan Jackson 2
1
Institute for Cancer Studies Christie
Hospital NHS Foundation Trust, University of Manchester,
Manchester, United Kingdom,
2
Wolfson
Molecular Imaging Centre, University of Manchester,
Manchester, Greater Manchester, United Kingdom,
3
Centre
for Imaging sciences & Biomedical Imaging Institute,
University of Manchester, United Kingdom
This study used DCE-MRI to compare the microvascular
characteristics of liver secondaries in patients with
advanced colorectal cancer. We particularly wished to
demonstrate whether differences could be detected
between liver secondaries in the same patient or between
liver secondaries in different patients, using standard
DCE-MRI techniques employed for clinical trials. In
order to test this hypothesis we developed a statistical
method which incorporated information on the measurement
reproducibility and error for median values of
parameters Ktrans, ve, vp, EF and ADC. There was more
variability between liver secondaries in different
patients than there was between secondaries in the same
patient.
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