Abstract #1079
Metabolic profiling of Urinary Bladder Carcinoma Tissues by HRMAS NMR spectroscopy
Abhinav Arun Sonkar 1 , Shatakshi Srivastava 2 , Raja A Roy 2 , Yadvendr A Dheer 1 , and Nuzhat A Husain 3
1
Surgery, King George's Medical University,
Lucknow, Uttar Pradesh, India,
2
Center
for Biomedical research, SGPGI, Lucknow, Uttar Pradesh,
India,
3
Pathology,
RMLIMS, Lucknow, Uttar Pradesh, India
In the present work, proton HR-MAS NMR spectroscopic
studies of muscle non-invasive Urinary Bladder Carcinoma
(UBC) tissue specimens with simultaneous urine analysis
has been performed. The detailed metabolic profiling
demonstrated significant presence of taurine and
branched chain amino acids (BCAA) in tissues of 24
patients suffering from superficial UBC when compared
with 29 tissue specimens from the same subjects with
non-malignant biopsies. The proton NMR spectra were then
subjected to PCA and PLS-DA multivariate analysis. The
validated model allowed >85% correct classification of
malignant tissues when compared with gold standard
histopathological examinations.
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