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Abstract #1074

Quantitative DTI Tractography of prostate gland in prostate cancer patients

Alexey A Tonyushkin 1,2 , Sandeep S Hedgire 1 , Peter F Hahn 1 , Shahin Tabatabaei 1 , Mukesh G Harisinghani 1 , and Andrew JM Kiruluta 1,2

1 Radiology Dept., Massachusetts General Hospital, Harvard Medical School, Boston, MA, United States, 2 Physics Dept., Harvard University, Cambridge, MA, United States

Diffusion tensor imaging (DTI) is commonly used to perform tractography that allows visualizing neuronal fiber map in a brain. This technique seldom been used for other visceral organs. We applied DTI tractography to prostate MRI and developed a quantitative approach that is able to discriminate tumor vs. normal tissue for diagnostic purposes. We carried out HIPPA compliant retrospective study of N=25 men with biopsy proven prostate cancer. The results imply differences in tract number in tumor vs. normal gland. Since these differences are statistically significant we can design a novel imaging tool to determine aggressiveness of tumor during diagnostics.

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