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Abstract #1072

Triexponential function analysis on diffusion-weighted MRI in diagnosing prostate cancer

Yu Ueda 1 , Satoru Takahashi 2 , Naoki Ohno 3 , Katsusuke Kyotani 1 , Nobukazu Aoyama 1 , Hideaki Kawamitsu 1 , Yoshiko Ueno 2 , Kazuhiro Kitajima 2 , Fumi Kawakami 4 , Tomoyuki Okuaki 5 , Toshiaki Miyati 3 , and Kazuro Sugimura 2

1 Division of Radiology, Kobe University Hospital, Kobe, Hyogo, Japan, 2 Department of Radiology, Kobe University Hospital, Kobe, Hyogo, Japan, 3 Faculty of Health Sciences, Institute of Medical, Pharmaceutical, and Health Sciences, Kanazawa University, Kanazawa, Ishikawa, Japan, 4 Department of Diagnostic Pathology, Kobe University Hospital, Kobe, Hyogo, Japan, 5 Philips Healthcare Asia Pacific, Minato-ku, Tokyo, Japan

To evaluate the clinical usefulness of triexponential function analysis of diffusion weighted MRI for the prostate cancer in the peripheral zone (PZ), we analyzed three diffusion coefficients (Dp, Df, Ds) and fractions (Fp, Ff, Fs), and compared them with the extra- and intracellular component information measured with the histopathological specimens and pharmacokinetic parameters calculated with DCE-MRI. Triexponential analysis would provide more detailed information on diffusion and perfusion of prostate cancer noninvasively. Moreover, our findings suggested that the reduction of ADC in PZ cancer would be due to the decrease of Ds that reflects intracellular diffusion.

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