Abstract #1061
Carbon Ion Radiation Therapy for Patients with Localized Prostate Cancer:
Maya B Wolf 1 , Timur H Kuru 2 , Gregor Habl 3 , and Matthias C Roethke 1
1
Radiology, DKFZ, Heidelberg,
Baden-Wrttemberg, Germany,
2
Urology,
University Hospital Heidelberg, Heidelberg,
Baden-Wrttemberg, Germany,
3
Radiation
Oncology, University Hospital Heidelberg, Heidelberg,
Baden-Wrttemberg, Germany
Purpose was to assess T2- and diffusion-weighted imaging
(DWI) after carbon ion therapy (CIT) of prostate cancer
(PCa) for treatment monitoring. Multiparametric MRI
including T2 and DWI at 3T were acquired prior to and
following CIT in patients with histologically confirmed
PCa. Statistical analysis of region of interest data
showed T2w signal loss at the 6 months interval and
immediate, as well as, continuous apparent diffusion
coefficient (ADC) increase after treatment in PCa areas.
PSA was inversely correlated with ADC values. The
results suggest that ADC could serve as an imaging
biomarker for assessing therapeutic response of PCa to
CIT.
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