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Abstract #1058

Using MRI to characterize lymphatic structure and function without exogenous contrast agents

Paula Donahue 1 , Swati Rane 2 , Seth Smith 2 , and Manus Donahue 2

1 Physical Medicine and Rehabilitation, Dayani Center for Health and Wellness, Vanderbilt University School of Medicine, Nashville, TN, United States, 2 Radiology, Vanderbilt University School of Medicine, TN, United States

The overall objective of this work is to translate noninvasive imaging techniques for measuring brain structure and function to the lymphatic system to characterize axillary lymphatic vessel structure and interstitial protein accumulation in patients with breast cancer-related lymphedema (BCRL). To achieve this, a multi-faceted, noninvasive 3T MRI protocol for characterizing lymph node volume (DWIBS MRI), lymph vessel diameter (3D TSE), lymph flow velocity (spin labeling MRI), and interstitial protein accumulation (APT CEST MRI) are optimized and applied in healthy volunteers (n=10) and patients with BCRL (n=4).

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