Abstract #1039
Errors Associated with Followup Measurments of ADC in Assessing Response to Neoadjuvant Chemotherapy
Shelley Waugh 1 , Lukasz Priba 1 , and Sarah Vinnicombe 2
1
Medical Physics, Ninewells Hospital, Dundee,
Angus, United Kingdom,
2
Division
of Cancer Research, University of Dundee, Dundee, United
Kingdom
This study considers the use of apparent diffusion
coefficient (ADC) measures as an indicator of early
response to neoadjuvant chemotherapy. As ADC changes are
utilised in clinical practice, this investigation
considers the multiple factors that may influence these
measurements and could influence classification of
response according to RECIST criteria. Scanner
stability, scan-scan repeatability and intra-observer
repeatability are measured with reference to the order
of magnitude of ADC changes likely to be encountered in
clinical patients who respond, partially respond and
have stable disease.
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