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Abstract #1039

Errors Associated with Followup Measurments of ADC in Assessing Response to Neoadjuvant Chemotherapy

Shelley Waugh 1 , Lukasz Priba 1 , and Sarah Vinnicombe 2

1 Medical Physics, Ninewells Hospital, Dundee, Angus, United Kingdom, 2 Division of Cancer Research, University of Dundee, Dundee, United Kingdom

This study considers the use of apparent diffusion coefficient (ADC) measures as an indicator of early response to neoadjuvant chemotherapy. As ADC changes are utilised in clinical practice, this investigation considers the multiple factors that may influence these measurements and could influence classification of response according to RECIST criteria. Scanner stability, scan-scan repeatability and intra-observer repeatability are measured with reference to the order of magnitude of ADC changes likely to be encountered in clinical patients who respond, partially respond and have stable disease.

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