Abstract #1017
Evidence for a cerebral blood flow post-stimulus undershoot contributing to the BOLD undershoot
Valerie E.M. Griffeth 1 and Richard B. Buxton 1
1
Keck Center for fMRI, University of
California, San Diego, La Jolla, CA, United States
Since the discovery of the blood oxygenation level
dependent (BOLD) signal, it has been noted that there is
a post-stimulus undershoot. The source of this
undershoot is often debated as it is unclear whether it
is a neurologic, vascular or metabolic phenomenon. Here
we provide evidence for a post-stimulus CBF undershoot
by combining data from multiple experiments examining
the response in the visual cortex to high contrast
flickering checkerboard stimuli. These results suggest
that previous publications may have missed CBF
undershoots either due to lack of study power or imaging
parameters not optimized for detecting the CBF signal.
This abstract and the presentation materials are available to members only;
a login is required.
Join Here
