Abstract #1003
Assessment of pancreatic islets using optical projection tomography and magnetic resonance imaging
JanakiRaman Rangarajan 1,2 , Ting Yin 3,4 , Josephine Gilbert 5 , Ashwini Atre 3,4 , Anna Eriksson 5 , Tom Dresselaers 3,4 , Frederik Maes 1 , Ulf Ahlgren 5 , and Uwe Himmelreich 3,4
1
ESAT/PSI - Medical Image Computing, KU
Leuven, Leuven, Belgium,
2
iMinds-KU
Leuven Future Health Department, KU Leuven, Leuven,
Belgium,
3
Biomedical MRI unit, Department of
Imaging and Pathology, KU Leuven, Belgium,
4
Molecular
Small Animal Imaging Center (MoSAIC), KU Leuven,
Belgium,
5
Ume
Centre for Molecular Medicine, Umea University, Sweden
Islet graft transplantation is an promising treatment
practice for diabetic treatment, but progressive islet
loss is a major issue, which drives the interest to
study islet location and function in vivo. MRI offers
high spatial resolution for in vivo assessment of
pancreatic islets (PI) labeled with iron-oxide
particles, but the quantification of PIs in MR is
confounded by the false positive signals. Optical
projection tomography (OPT) offers multi-spectral
assessment of PI labeled with fluorescent markers, but
only allow ex vivo measurements. Using spatial
normalization methods, we co-register the multi-modal
data of MRI and OPT, which allowed co-localization of
PIs. The. successful co-registration of pancreatic
tissue allowed cross-validation of PIs in MR images,
confirming its suitability for in vivo PI imaging. This
is an essential prerequisite for future validation of in
vivo MRI data using beta-cell targeting iron oxide based
nanoparticles
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