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Abstract #0998

Optimization of 3D turbo GluCEST MRI of healthy brain at 7T

Kejia Cai 1,2 , Hari Hariharan 1 , Anup Singh 1 , Mohammad Haris 1,3 , Kevin D'Aquilla 1 , Ravi Prakash Reddy Nanga 1 , Feliks Kogan 1 , and Ravinder Reddy 1

1 Radiology, University of Pennsylvania, Philadelphia, PA, United States, 2 CMRR 3T Research Program, Radiology, University of Illinois at Chicago, Illinois, IL, United States, 3 Sidra Medical and Research Center, Doha, Qatar, United States

Glutamate (Glu) is the primary neurotransmitter responsible for excitatory synaptic transmission in the central nervous system. Excessive Glu in the synaptic space can trigger a toxic cascade leading to neuronal death, which has been implicated in a wide range of neurological and psychiatric disorders. GluCEST, an imaging technique that utilizes the chemical exchange saturation effect of Glu has been exploited for mapping single-slice Glu in brain and spinal cord at the ultra-high field 7T. However, 3D GluCEST mapping may be necessary to localize Glu abnormalities in a large brain volume. The purpose of this study is to extend the 2D GluCEST for 3D imaging. A turbo acquisition method has been investigated and optimized for scan time efficiency.

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