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Abstract #0976

In vivo investigations of accuracy and precision of fiber orientations in crossing fibers in spherical deconvolution-based HARDI methods

Sjoerd B. Vos 1 , Chantal M.W. Tax 1 , Martijn Froeling 2 , and Alexander Leemans 1

1 Image Sciences Institute, University Medical Center Utrecht, Utrecht, Utrecht, Netherlands, 2 Department of Radiology, University Medical Center Utrecht, Utrecht, Utrecht, Netherlands

Recently, acquisition and processing parameters have been proposed to optimally describe the angular profile of diffusion-weighted signal profiles in single-fiber voxels. We present an overview of how these factors affect fODF estimation in crossing-fiber voxels in vivo, investigating both the accuracy and precision of reconstructed fODF peaks. Higher b-values provide high levels of precision and accuracy, even for low number of DWIs (50-100). On the whole, more directions at lower b-values performed to similar levels of precision. However, the longer diffusion-weighting pulses for higher b-values likely cost less scan time than the increased number of DWIs required at lower b-values.

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