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Abstract #0974

Histological Relationship with High-Resolution Diffusion Kurtosis Imaging in the Cerebral Cortex

Austin Ouyang 1 , Xinzeng Wang 1 , Mihovil Pletikos 2 , Nenad Sestan 2 , and Hao Huang 1

1 Advanced Imaging Research Center, University of Texas Southwestern Medical Center, Dallas, Texas, United States, 2 Department of Neurobiology, Yale University, New Haven, CT, United States

Diffusion kurtosis imaging (DKI) provides greater sensitivity to microstructural differences due to its capability of quantifying non-Gaussian diffusion properties; however, the biological interpretation of these DKI metrics has yet to be fully characterized, especially in the cerebral cortex. In this study, we acquired high resolution DKI data of a macaque brain and compared the DKI metrics with histological image of neurofilament staining. Slices with large cortical variations in mean kurtosis (MK) corresponded well with the density of neurofilament staining.

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