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Abstract #0972

Non-Gaussian diffusion in complex systems: results in bone marrow samples

Marco Palombo 1,2 , Valentina Di Marco 1,2 , Giulia Di Pietro 1,2 , and Silvia Capuani 1,2

1 Physics Department, Sapienza University, Rome, Rome, Italy, 2 CNR IPCF UOS Roma Sapienza, Physics Department Sapienza University, Rome, Rome, Italy

We studied the potential of Gaussian and non-Gaussian diffusion methods to obtain microstructural information and water compartmentalization in bone-marrow filling pores in cancellous bone (TBM) and not forced in pores (FBM), by investigating water and fat ADC, and lower case Greek gamma stretched parameter of the anomalous diffusion model, as a function of diffusion time. We used four TBM and seven FBM samples extracted from calves, to show the ability of Gaussian and non-Gaussian diffusion methods to characterize and discriminate different bone-marrow samples and to highlight that lower case Greek gamma is highly correlated to intrinsic local microstructural features at the interface between water and bone.

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