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Abstract #0967

3D High Resolution Diffusion-Weighted MRI at 3T: Preliminary Application in Patients undergoing Active Surveillance Protocol for Low-Risk Prostate Cancer

Christopher Nguyen 1,2 , Zhaoyang Fan 1 , Ali Afshar 3 , Yibin Xie 1,2 , Rola Saouaf 4 , Hyung Kim 3 , and Debiao Li 1,2

1 Biomedical Imaging Research Institute, Cedars-Sinai Medical Center, Los Angeles, CA, United States, 2 Bioengineering, University of California Los Angeles, Los Angeles, CA, United States, 3 Surgery, Urology Division, Cedars-Sinai Medical Center, Los Angeles, CA, United States, 4 Radiology, Cedars-Sinai Medical Center, Los Angeles, CA, United States

We developed a novel 3D diffusion-prepared multi-shot balanced steady-state free precession technique capable of improved spatial resolution, image quality, and lesion contrast-to-noise ratio compared with single-shot diffusion-weighted echo planar imaging (SS DW EPI), while maintaining quantitative estimation of trace apparent diffusion coefficient. Because of these technical advances, the proposed technique yielded significantly better sensitivity, PPV, NPV, and AUC in detecting biopsy-confirmed lesions compared with SS DW EPI in a small group of prostate cancer patients undergoing active surveillance (AS-PC). By improving lesion detection, the proposed technique may allow DW MRI to potentially monitor low-risk prostate cancer lesions in AS-PC.

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