Abstract #0960
STRUCTURAL MRI CORRRELATES OF COGNITIVE IMPAIRMENT IN PATIENTS WITH MULTIPLE SCLEROSIS: A MULTI CENTER STUDY
Elisabetta Pagani 1 , Maria A. Rocca 1 , Paolo Preziosa 1 , Matteo Atzori 2 , Frederik Barkhof 3 , Nicola De Stefano 4 , Christian Enzinger 5 , Franz Fazekas 6 , Antonio Gallo 7 , Hanneke Hulst 3 , Laura Mancini 2 , Xavier Montalban 8 , Alex Rovira 9 , Maria Laura Stromillo 4 , Gioacchino Tedeschi 7 , Giancarlo Comi 10 , and Massimo Filippi 1
1
Neuroimaging Research Unit, Institute of
Experimental Neurology, San Raffaele Scientific
Institute, Vita-Salute San Raffaele University, Milan,
MI, Italy,
2
Dept. Brain Repair and
Rehabilitation, Institute of Neurology, UCL, London, GB,
United Kingdom,
3
Department
of Radiology, Free University Medical Centre, Amsterdam,
NL, Netherlands,
4
Department
of Neurological and Behavioral Sciences, University of
Siena, Siena, SI, Italy,
5
Division
of Neuroradiology, Medical University of Graz, Graz, AT,
Austria,
6
Department
of Neurology, Medical University of Graz, Graz, AT,
Austria,
7
Department
of Medical, Surgical, Neurological, Metabolic and Aging
Sciences, Second University of Naples, Naples, NA,
Italy,
8
Department
of Neurology-Neuroimmunology, Vall dHebron University
Hospital, Barcelona, CT, Spain,
9
Department
of Radiology, Vall dHebron University Hospital,
Barcelona, CT, Spain,
10
Department
of Neurology, San Raffaele Scientific Institute,
Vita-Salute San Raffaele University, Milan, MI, Italy
Voxel-wise analysis to high-resolution 3DT1-weighted and
diffusion tensor (DT)-MRI scans were applied to assess
the structural correlates of cognitive dysfunction in
multiple sclerosis (MS) patients and their validity in a
multicenter setting. Twenty-three (37%) MS patients were
classified as cognitively impaired (CI). Compared to
cognitively preserved and controls, CI patients had
atrophy of several deep gray matter nuclei, fronto-parietal
regions and the corpus callosum (CC). Voxel-based
approaches to define the regional distribution of brain
damage in a multicenter setting in MS patients is
feasible, contributing to better characterize disease
clinical manifestations, including cognitive impairment.
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