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Abstract #0953

Hyperoxygenation in combination with susceptibility weighted imaging identifies vascular lesions in a model of multiple sclerosis

Nabeela Nathoo 1 , James A. Rogers 2 , V. Wee Yong 2 , and Jeff F. Dunn 1,3

1 Radiology, University of Calgary, Calgary, Alberta, Canada, 2 Clinical Neurosciences, University of Calgary, Calgary, Alberta, Canada, 3 Experimental Imaging Centre, University of Calgary, Calgary, Alberta, Canada

We showed previously that susceptibility weighted imaging (SWI) detects two types of lesions in the experimental autoimmune encephalomyelitis (EAE) model of multiple sclerosis: 1) vascular lesions, due to intravascular deoxyhemoglobin, and 2) parenchymal white matter lesions, due to iron deposition/demyelination. To identify vascular lesions in vivo, high oxygen was used during SWI MRI in EAE mice. High oxygen changed the appearance of vascular lesions, making them either disappear, become less dark, or become bright. As hyperoxygenation is well tolerated and safe, this method could be translated to MS patients to help differentiate between sources of lesions seen with SWI.

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