Abstract #0953
Hyperoxygenation in combination with susceptibility weighted imaging identifies vascular lesions in a model of multiple sclerosis
Nabeela Nathoo 1 , James A. Rogers 2 , V. Wee Yong 2 , and Jeff F. Dunn 1,3
1
Radiology, University of Calgary, Calgary,
Alberta, Canada,
2
Clinical
Neurosciences, University of Calgary, Calgary, Alberta,
Canada,
3
Experimental
Imaging Centre, University of Calgary, Calgary, Alberta,
Canada
We showed previously that susceptibility weighted
imaging (SWI) detects two types of lesions in the
experimental autoimmune encephalomyelitis (EAE) model of
multiple sclerosis: 1) vascular lesions, due to
intravascular deoxyhemoglobin, and 2) parenchymal white
matter lesions, due to iron deposition/demyelination. To
identify vascular lesions in vivo, high oxygen was used
during SWI MRI in EAE mice. High oxygen changed the
appearance of vascular lesions, making them either
disappear, become less dark, or become bright. As
hyperoxygenation is well tolerated and safe, this method
could be translated to MS patients to help differentiate
between sources of lesions seen with SWI.
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