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Abstract #0920

Quantitative DCE-MRI Assessment of Breast Cancer Response to Neoadjuvant Chemotherapy

Alina Tudorica 1 , Karen Y Oh 1 , Stephen Y-C Chui 1 , Nicole Roy 1 , Megan L Troxell 1 , Yiyi Chen 1 , Arpana Naik 1 , Megan L Holtorf 1 , Aneela Afzal 1 , Zunqiu Chen 1 , Charles S Springer 1 , Xin Li 1 , and Wei Huang 1

1 Oregon Health & Science University, Portland, Oregon, United States

Fifteen women with breast cancer underwent DCE-MRI before, during, and after neoadjuvant chemotherapy. Pharmacokinetic analysis of DCE-MRI data were performed using Standard (Tofts) model (SM) and Shutter-Speed model (SSM). After only one cycle of therapy, % changes in SM and SSM Ktrans and kep, and SSM-unique Tau_i, as well as absolute values of Ktrans and kep, provieded excellent early predictions of pathologic complete response. Following therapy completion, tumor Tau_i was inversely, while Ktrans and tumor size were positively, correlated with residual disease burden. In conclusion, DCE-MRI functional parameters provided earlier prediction of response and more accurate assessment of residual disease compared to tumor size measurement.

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