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Abstract #0904

Diffusion abnormalities in the spinal cord grey matter relates to disability in relapse-onset multiple sclerosis

Hugh Kearney 1 , Torben Schneider 1 , Marios C. Yiannakas 1 , Claudia A.M. Wheeler-Kingshott 1 , Olga Ciccarelli 1,2 , and David H. Miller 1,2

1 NMR Research Unit, UCL Institute of Neurology, London, United Kingdom, 2 NIHR University College London Hospitals Biomedical Research Centre, London, United Kingdom

We have quantified spinal cord abnormalities in people with relapse-onset multiple sclerosis (MS) using diffusion tensor imaging (DTI) in specific white matter and grey matter tracts. Abnormal DTI metrics were evident in the spinal cord of people with clinically isolated syndrome prior to the accumulation of significant levels of physical disability. In both relapsing remitting and secondary progressive MS, DTI values also differed significantly from controls. In the MS cohort (i.e. excluding CIS) there were a number of significant correlations with physical disability in both white matter tracts and the central spinal cord grey matter.

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