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Abstract #0899

In vivo QSM in early-stage Alzheimers disease reveals magnetostatic alterations in the basal ganglia and beyond

Julio Acosta-Cabronero 1 , Guy B Williams 2 , Arturo Cardenas-Blanco 1 , and Peter J Nestor 1

1 Brainplasticity & Neurodegeneration, German Center for Neurodegenerative Diseases (DZNE), Magdeburg, Saxony-Anhalt, Germany, 2 Wolfson Brain Imaging Centre, University of Cambridge, Cambridge, Cambridgeshire, United Kingdom

This study explores the magnetostatic properties of the Alzheimers disease (AD) brain using quantitative susceptibility mapping (QSM) a post-processed MRI contrast that has the potential to monitor in vivo iron levels by reconstructing magnetic susceptibility sources from field perturbations. The regional and whole-brain cross-sectional comparisons between AD subjects and matched controls indicate that there may be significant magnetic susceptibility differences for deep brain nuclei particularly the putamen as well as for posterior grey and white matter regions. In addition, the methodology and findings described suggest that the QSM method is ready for larger-scale clinical studies.

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