Abstract #0899
In vivo QSM in early-stage Alzheimers disease reveals magnetostatic alterations in the basal ganglia and beyond
Julio Acosta-Cabronero 1 , Guy B Williams 2 , Arturo Cardenas-Blanco 1 , and Peter J Nestor 1
1
Brainplasticity & Neurodegeneration, German
Center for Neurodegenerative Diseases (DZNE), Magdeburg,
Saxony-Anhalt, Germany,
2
Wolfson
Brain Imaging Centre, University of Cambridge,
Cambridge, Cambridgeshire, United Kingdom
This study explores the magnetostatic properties of the
Alzheimers disease (AD) brain using quantitative
susceptibility mapping (QSM) a post-processed MRI
contrast that has the potential to monitor in vivo iron
levels by reconstructing magnetic susceptibility sources
from field perturbations. The regional and whole-brain
cross-sectional comparisons between AD subjects and
matched controls indicate that there may be significant
magnetic susceptibility differences for deep brain
nuclei particularly the putamen as well as for
posterior grey and white matter regions. In addition,
the methodology and findings described suggest that the
QSM method is ready for larger-scale clinical studies.
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