Abstract #0893
Susceptibility and Relaxation Tensor Properties of Multiple Sclerosis Lesions at 3T
Cynthia Wisnieff 1 , Alexey Dimov 1,2 , David Pitt 3 , and Yi Wang 1,2
1
Biomedical Engineering, Cornell University,
Ithaca, New York, United States,
2
Radiology,
Weill Cornell Medical College, New York, New York,
United States,
3
Neurology,
Yale University, New Haven, Connecticut, United States
This preliminary data explores changes in the
susceptibility (STI) and relaxation tensor (R2*T)
properties of multiple sclerosis (MS) lesions in MRI as
a result of structural changes that occur as a result of
demyelinating process that occurs within these lesions.
Ex vivo brain specimens were examined in an
unconstrained susceptibility and relaxation tensor
reconstruction to explore changes in the anisotropy,
alignment and mean tensor properties were examined. This
works shows significant loss of alignment within lesions
while major white matter tracts retain significant
alignment and anisotropy.
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