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Abstract #0881

Quantitative 3D Myocardial Perfusion Imaging at High Dose with Accurate Arterial Input Function Assessment

Lukas Wissmann 1 , Markus Niemann 1,2 , Robert Manka 1,2 , and Sebastian Kozerke 1,3

1 Institute for Biomedical Engineering, University and ETH Zurich, Zurich, Switzerland, 2 Department of Cardiology, University Hospital Zurich, Zurich, Switzerland, 3 Division of Imaging Sciences & Biomedical Engineering, King's College London, London, United Kingdom

First-pass myocardial perfusion imaging requires high contrast agent dose to achieve sufficient contrast-to-noise ratio for reliable qualitative diagnosis. On the other hand, myocardial blood flow quantification at high dose suffers from signal saturation. In conventional approaches this results in underestimation of the peak arterial input function, leading to overestimation of myocardial blood flow. The study at hand presents an interleaved 2D AIF navigator for whole-heart 3D perfusion imaging. It is demonstrated that accurate quantification of blood flow is achieved while maintaining excellent contrast-to-noise ratios for simultaneous qualitative assessment with high-dose contrast injections.

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