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Abstract #0876

Diagnosis of diastolic dysfunction by shear wave amplitudes measured in cardiac MR elastography

Thomas Elgeti 1 , Fabian Knebel 2 , Ingo Steffen 1 , Bernd Hamm 1 , Jrgen Braun 3 , and Ingolf Sack 1

1 Department of Radiology, Charit Universittsmedizin Berlin, Berlin, Germany, 2 Department of Cardiology and Angiology, Charit Universittsmedizin Berlin, Berlin, Germany, 3 Department of Medical Informatics, Charit Universittsmedizin Berlin, Berlin, Germany

Cardiac MR elastography (cMRE) can detect altered mechanical tissue properties, which cause diastolic dysfunction. In this study, time harmonic shear wave amplitudes (SWA) were measured in 50 subjects including 30 patients with cardiac relaxation abnormalities by cMRE for the quantification of the symptomatic and asymptomatic ability of the myocardium to mechanically relax. Compared to controls, patients displayed significantly reduced SWA which was inversely correlated to the severity of diastolic dysfunction. Best cutoff-value to differentiate between volunteers and patients was 0.43 yielding an AUROC value of 0.92 with 90% sensitivity and 89.7% specificity.

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