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Abstract #0861

Abnormal postprandial response of ascending colon volume in patients with Irritable bowel syndrome with diarrhoea

Susan E Pritchard 1 , Luca Marciani 2 , Klara C Garsed 3 , Caroline L Hoad 1 , Wanvipa Thongborisute 2 , Emily Roberts 2 , Robin C Spiller 2,3 , and Penny A Gowland 1

1 Sir Peter Mansfield Magnetic Resonance Centre, University of Nottingham, Nottingham, United Kingdom, 2 Nottingham Digestive Diseases Centre, School of Clinical Sciences, University of Nottingham, United Kingdom, 3 Nottingham Digestive Diseases Biomedical Research Unit, University of Nottingham, Nottingham, United Kingdom

Previous assessments of colon morphology have had limitations. We carried out serial MRI regional volume measurements of the undisturbed fasted and fed colon of healthy volunteers and patients with diarrhoea predominant irritable bowel syndrome (IBS-D). While the ascending colon expanded 10% immediately after eating in healthy subjects this increase was not seen in IBS-D patients implying failure to accommodate ileal inflow which may account for the faster colonic transit in IBS-D. Assessing colon form and function has great potential to identify biomarkers and stratify patients and also for validating both pharmacological and dietary disease management.

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