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Abstract #0830

Feasibility and Reproducibility of Measurement of Skeletal Muscle Blood Flow, Oxygen Extraction and VO2 with Dynamic Exercise Using MRI

Kory W. Mathewson 1 , Mark Haykowsky 2 , and Richard B. Thompson 1

1 Biomedical Engineering, University of Alberta, Edmonton, Alberta, Canada, 2 Faculty of Rehabilitation, University of Alberta, Edmonton, Alberta, Canada

We propose a new imaging approach which interleaves complex-difference and susceptometry MRI acquisitions for real-time imaging of skeletal muscle blood flow (SMBF) and venous oxygen saturation (SvO2) for the calculation of skeletal muscle oxygen consumption (VO2). The goal of this study was to determine the reproducibility of this approach during sub-maximal knee-extensor exercise. The coefficient of variation from test/retest trials was 7.6%, 15.6% and 12.3% for SMBF, SvO2 and VO2, with mean values of 0.90.1L/min/kg, 43.213.5% and 95.718.0mL/min/kg respectively. To our knowledge, this is the first report of non-invasive skeletal muscle VO2 and its determinants (SMFB,SvO2) during dynamic exercise.

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