Abstract #0815
Morphological and quantitative ultrashort echo time (UTE) magnetic resonance imaging of the short T2 components in white matter of the brain
Jiang Du 1 , Vipul Sheth 1 , Shihong Li 1 , Michael Carl 2 , Scott Vandenberg 3 , Jody Corey-Bloom 4 , and Graeme Bydder 1
1
Radiology, University of California, San
Diego, San Diego, CA, United States,
2
General
Electric, Global MR Applications & Workflow, San Diego,
CA, United States,
3
Pathology,
University of California, San Diego, La Jolla, CA,
United States,
4
Neurosciences,
University of California, San Diego, La Jolla, CA,
United States
Myelin is a lamellar membranous structure consisting of
alternating protein and lipid layers. Researchers have
been working for decades to develop MRI techniques to
assess myelin in vivo. The non-water protons in myelin
and tightly bound water have very short T2s and are
invisible with conventional clinical sequences. We
have implemented a 2D adiabatic inversion recovery
prepared dual echo ultrashort echo time (2D IR-dUTE)
acquisition with a TE of 8 us. In this study we aimed to
morphologically and quantitatively evaluate myelin and
tightly bound water in white matter of the brain of
normal volunteers at 3T.
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