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Abstract #0813

Accuracy and precision analysis in spectral fitting - a lesson learned from ProFit

Milan Scheidegger 1,2 , Alexander Fuchs 1 , and Anke Henning 1,3

1 Institute for Biomedical Engineering, University and ETH Zurich, Zurich, Zurich, Switzerland, 2 Department of Psychiatry, Psychotherapy, and Psychosomatics, University Hospital of Psychiatry Zurich, Zurich, Switzerland, 3 Max Planck Institute for Biological Cybernetics, Tbingen, Baden-Wrtemberg, Germany

This work demonstrates that both accuracy and precision are important to evaluate for performance validation of spectral fitting packages as demonstrated on the example of ProFit a spectral fitting package for 2D JPRESS. Strong regularization or tight constraints as implemented in different commercial or freely available spectral fitting routines can lead to small coefficients of variance but strong bias of the quantification results which hinder the detection of naturally occurring variance of metabolite concentrations.

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