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Abstract #0803

Grid structure of brain pathways Validation and the character of turns

Van Jay Wedeen 1 , Farzad Mortazavi 2 , Ruopeng Wang 1 , Wen-Yih Isaac Tseng 3 , Thomas Witzel 1 , Aapo Nummenmaa 1 , William Morrison 4 , H Eugene Stanley 4 , Lawrence Wald 1 , and Douglas Rosene 2

1 Radiology, Massachusetts General Hospital, Charlestown, MA, United States, 2 Anatomy and Neurobiology, Boston University, Boston, MA, United States, 3 Center for Optoelectronic Biomedicine, National Taiwan University, Taipei, Taiwan, 4 Boston Unviersity, Boston, United States

Recently it has been found that the fiber pathways of the brain follow a curvilinear grid derived from the three axes of development. Here we present a method to objectively identify this structure among the brain pathways. For each voxel and pair of diffusion ODF maximum vectors, arrays of parallel crossing paths are constructed, and retained only where they form a 2D surface. In rhesus DSI, grid structure was demonstrated explicitly and extensively. In gyri, the preponderance of pathways followed rectilinear grid trajectories. These studies show grid structure can be objectively defined, and promise new quantitative strategies for MRI tractography.

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