Abstract #0797
Cellular Size Distributions Revealed by Non-Uniform Oscillating-Gradient Spin-Echo (NOGSE) MRI
Noam Shemesh 1 , Gonzalo A Alvarez 1 , and Lucio Frydman 1
1
Chemical Physics, Faculty of Chemistry,
Weizmann Institute of Science, Rehovot, Israel
Noninvasively characterizing cellular size distributions
is paramount since their features impact underlying
functional or biological capacities. Herein, we harness
Non-uniform-Oscillating-Gradient Spin-Echo
Magnetic-Resonance-Imaging (NOGSE MRI) a methodology
probing diffusion dynamics with extraordinary
sensitivity towards compartmental dimensions for
depicting size distributions in a simple,
one-dimensional experiment. Simulations and experiments
in yeast cells validate NOGSEs ability to faithfully
reconstruct cellular size distributions; NOGSE-derived
maps of size distribution properties in the mouse brain
reveal hallmark microstructural features in both white
and gray matter. NOGSEs exquisite sensitivity towards
length to the power of six renders it highly promising
for contrasting disease in-vivo from size distribution
contrast.
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