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Abstract #0787

Fat-Constrained Reconstruction of 18F FDG Accumulation in an Integrated PET/MR System using MR Dixon Imaging

Sven Prevrhal 1 , Susanne Heinzer 2 , Bndicte Delattre 2,3 , Steffen Renisch 4 , Christian Wlker 5 , Osman Ratib 3 , and Peter Brnert 1

1 Philips Research, Hamburg, Germany, 2 Philips AG Healthcare, Zurich, Switzerland, 3 University Hospital of Geneva, Geneva, Switzerland, 4 Philips Research, Hamburg, Deutschland, Germany, 5 University of Heidelberg, Germany

The fusion of the information from PET and MRI can increase the diagnostic value of both modalities. Compared to MRI, PET has limited spatial resolution, which could potentially be improved by using the information MRI can deliver. In this work the hypothesis was employed that fatty tissue is metabolically not very active in terms of glucose consumption. Thus, a PET tracer like 18F-deoxyglucose (FDG) has limited accumulation in fatty tissue and should have no significant PET signal in this compartment. Thus, the fat distribution measured in water/fat-resolved mDixon MRI can be used as a prior in an appropriately modified PET image reconstruction. Phantom and in vivo results show the basic feasibility of this approach.

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