Abstract #0778
In Vivo Monitoring of Mucus Obstruction and Ventilation Malfunction in Mice by Combined 1H and Hyperpolarized 129Xe-gas Lung MRI
Le Zhang 1 , Rosa Tamara Branca 2,3 , Ting He 2 , and Camille Ehre 4
1
Curriculum in Applied Science and
Engineering, University of North Carolina at Chapel
Hill, Chapel Hill, NC, United States,
2
Physics
and Astronomy, University of North Carolina at Chapel
Hill, Chapel Hill, NC, United States,
3
Biomedical
Research Imaging Center, University of North Carolina at
Chapel Hill, Chapel Hill, NC, United States,
4
Cystic
Fibrosis/Pulmonary Research and Treatment Center,
University of North Carolina at Chapel Hill, Chapel
Hill, NC, United States
A combination of ultrashort echo time proton imaging
technique and hyperpolarized 129Xenon MRI was presented
to detect mucus accumulation inside lungs of mice with
cystic fibrosis symptoms. Histology was also performed
to validate the findings.
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