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Abstract #0775

Dissolved Hyperpolarised 129Xe As A Probe Of Lung Function In Idiopathic Pulmonary Fibrosis And Systemic Sclerosis

Neil James Stewart 1 , General Leung 1 , Graham Norquay 1 , Helen Marshall 1 , Juan Parra-Robles 1 , Andy Swift 1 , Jan Wolber 1,2 , Rolf Schulte 3 , Nehal Hussain 4 , Robin Condliffe 4 , Charlie Elliot 4 , Philip Murphy 5 , Moira Whyte 4 , David Kiely 4 , and Jim Michael Wild 1

1 Academic Radiology, University of Sheffield, Sheffield, South Yorkshire, United Kingdom, 2 GE Healthcare, Amersham, Buckinghamshire, United Kingdom, 3 GE Global Research, Garching, Bavaria, Germany, 4 Respiratory Medicine, University of Sheffield, Sheffield, South Yorkshire, United Kingdom, 5 GlaxoSmithKline, Southall, Greater London, United Kingdom

In this work, hyperpolarised 129Xe was assessed as a functional tool for the study of gas exchange in the human lungs. The Chemical Shift Saturation Recovery technique was utilised to quantify changes in lung microstructure and consequent degradation of lung function in subjects with idiopathic pulmonary fibrosis and systemic sclerosis, via non-invasive measurement of septal thickening and elevated pulmonary-capillary transit times. The results of this study correlated well with dynamic contrast enhanced MRI and hyperpolarised 3He diffusion MRI.

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