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Abstract #0754

Modeling the hemodynamic response in stimulus-evoked mouse fMRI

Felix Schlegel 1 , Aileen Schroeter 1 , and Markus Rudin 1,2

1 Institute for Biomedical Engineering, ETH and University of Zrich, Zrich, Zrich, Switzerland, 2 Institute of Pharmacology and Toxicology, University of Zrich, Zrich, Zrich, Switzerland

For stimulus-evoked fMRI in mice, the standard analysis tools may not be appropriate as the intrinsic assumptions of linearity relating stimulus and hemodynamic response and the use fixed shapes of the hemodynamic response function (HRF) may not be valid. Here, we show how the sensitivity and specificity of BOLD fMRI in mice can be improved by employing appropriate experimental designs and analysis approaches. We found that in out data, event-related designs produce more specific responses than block designs and that nonlinear regression approaches outperform traditional methods like finite impulse responses, SPM basis functions or fixed HRF shapes.

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