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Abstract #0752

Regional quantification of cerebral venous oxygenation from MRI susceptibility mapping during hypercapnia

Audrey P Fan 1,2 , Karleyton C Evans 1,3 , Jeffrey N Stout 2,4 , Bruce R Rosen 2,4 , and Elfar Adalsteinsson 1,4

1 Electrical Engineering and Computer Science, Massachusetts Institute of Technology, Cambridge, MA, United States, 2 Radiology, Athinoula A. Martinos Center for Biomedical Imaging, Charlestown, MA, United States, 3 Psychiatry, Massachusetts General Hospital, Boston, MA, United States, 4 Health Sciences and Technology, Harvard-MIT, Cambridge, MA, United States

The purpose of the study was to validate regional measurements of oxygen extraction fraction (OEF) in individual cerebral veins derived from quantitative susceptibility mapping. Flow-compensated gradient echo images and arterial spin labeling perfusion images were acquired during eucapnia and moderate hypercapnia in eight healthy volunteers. Regional changes in perfusion were used to predict local oxygenation changes and compared with quantitative susceptibility mapping (QSM)-based OEF estimates in veins draining the cingulate, occipital, parietal, and frontal cortices. Measured OEF changes during hypercapnia from MR susceptibility show good agreement with predictions based on regional flow observations and no change in the cerebral metabolic rate of oxygen CMRO 2 , and suggests that regional estimates of OEF in vessels from QSM maps are reliable.

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