Meeting Banner
Abstract #0731

Fixel-Based Morphometry: Whole-Brain White Matter Morphometry in the Presence of Crossing Fibres

David Raffelt 1 , Robert E Smith 1 , Donald Tournier 1,2 , David Vaughan 1,3 , Graeme Jackson 1,3 , and Alan Connelly 1,2

1 Florey Institute of Neuroscience and Mental Health, Melbourne, VIC, Australia, 2 Department of Medicine, University of Melbourne, Melbourne, VIC, Australia, 3 Department of Neurology, Austin Health, Melbourne, VIC, Australia

When investigating morphometric white matter differences between populations, the direction of expansion or contraction relative to the underlying fibre tract is important. Expansion or contraction parallel to the fibre orientation implies a difference in axon length, while a change to the cross sectional area (CSA) in the perpendicular plane implies a difference in the number of axons and is therefore more relevant. We propose a method that uses Fibre Orientation Distributions to resolve multiple populations of fibres within each voxel (fixels). We perform whole-brain statistical comparisons of the change in fixel CSA across groups in a method called fixel-based morphometry.

This abstract and the presentation materials are available to members only; a login is required.

Join Here