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Abstract #0728

Estimation of the True Arterial Input Function using a Physiological Model in Dynamic Contrast Enhanced MRI

Dennis Lai-Hong Cheong 1 , Bo Zhang 1 , Limiao Jiang 1,2 , and Thian C Ng 1,2

1 Clinical Imaging Research Center, A*STAR & National University of Singapore, 117456, Singapore, 2 Department of Diagnostic Radiology, National University of Singapore, 119074, Singapore

It is challenging to find an appropriate AIF in DCE MRI studies. Ideally, AIF is the contrast concentration time curve in incoming blood at the tissue of interest, but this is not measurable directly with current technologies. We estimated the true AIF using a physiological model for AIF that we have developed recently. The model gave good fittings to all concentration time curves measured at vessels. The estimated true AIF was used in tracer kinetic analysis using both a distributed parameter model and the modified Tofts model. This method offers a way to estimate the true AIF at the tissue of interest.

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