Abstract #0728
Estimation of the True Arterial Input Function using a Physiological Model in Dynamic Contrast Enhanced MRI
Dennis Lai-Hong Cheong 1 , Bo Zhang 1 , Limiao Jiang 1,2 , and Thian C Ng 1,2
1
Clinical Imaging Research Center, A*STAR &
National University of Singapore, 117456, Singapore,
2
Department
of Diagnostic Radiology, National University of
Singapore, 119074, Singapore
It is challenging to find an appropriate AIF in DCE MRI
studies. Ideally, AIF is the contrast concentration time
curve in incoming blood at the tissue of interest, but
this is not measurable directly with current
technologies. We estimated the true AIF using a
physiological model for AIF that we have developed
recently. The model gave good fittings to all
concentration time curves measured at vessels. The
estimated true AIF was used in tracer kinetic analysis
using both a distributed parameter model and the
modified Tofts model. This method offers a way to
estimate the true AIF at the tissue of interest.
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