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Abstract #0723

Brain tumor oxygen saturation mapping with magnetic resonance imaging corrected by a local hematocrit mapping assessed by nuclear imaging

Benjamin Lemasson 1,2 , Alexis Broisat 3,4 , Pauline Busieau 1,2 , Rgine Farion 1,2 , Mitra Ahmadi 3,4 , Sandrine Bacot 3,4 , Catherine Ghezzi 3,4 , Chantal Rmy 1,2 , and Emmanuel Barbier 1,2

1 U836, Inserm, GRENOBLE, France, 2 Grenoble Institut des Neurosciences, Universit Joseph Fourier, GRENOBLE, France, 3 U1039, Inserm, GRENOBLE, France, 4 Radiopharmaceutiques Biocliniques, Universit Joseph Fourier, GRENOBLE, France

We evaluated the impact of the local hematocrit (Hct) when mapping the brain tumor oxygen saturation (StO 2 ). A multimodal experiment (MRI and autoradiography of 2 different isotopes) was performed on 8 rats bearing a brain tumor. The tumor Hct level, assessed by autoradiography, was significantly reduced as compared to healthy striatum. Using, for each animal, the Hct to compute the StO 2 voxel-wise led to a significant reduction in tumor oxygenation in comparison to that of the healthy striatum. Our results indicate that change in Hct should not be overlooked when assessing oxygenation in brain tumors or in other brain diseases.

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