Abstract #0711
Use of DW Imaging as an Adjunct to Dynamic Contrast Enhanced MRI in Breast Cancer at 3T
Sunitha Thakur 1 , Soledad Milans 2 , Sujata Patil 3 , and Elizabeth Morris 3
1
Memorial Sloan-Kettering Cancer Center, New
York, NY, United States,
2
Memorial
Sloan-Kettering Cancer Center, New York, United States,
3
Memorial
Sloan-Kettering Cancer Center, NY, United States
DWI has demonstrated potential in discriminating
malignant from benign lesions. In this work we explored
if DWI can improve PPV of contrast-enhanced MRI at 3.0
T. ADC values are significantly lower in malignant
lesions compared to benign lesions yielding 86%
sensitivity, 73% specificity, 86% PPV and 73% NPV with
the optimal ADC threshold of 1.3x10
-3
mm
2
/s
derived from ROC analysis. Higher mean ADC values were
observed in DCIS lesions compared to invasive lesions,
and low-risk benign compared with high risk benign
lesions. DWI of lesion assessment improves the PPV of
breast malignancy and can be used as an adjunct to MRI (PPV=34%)
to avoid unnecessary benign biopsies.
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