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Abstract #0711

Use of DW Imaging as an Adjunct to Dynamic Contrast Enhanced MRI in Breast Cancer at 3T

Sunitha Thakur 1 , Soledad Milans 2 , Sujata Patil 3 , and Elizabeth Morris 3

1 Memorial Sloan-Kettering Cancer Center, New York, NY, United States, 2 Memorial Sloan-Kettering Cancer Center, New York, United States, 3 Memorial Sloan-Kettering Cancer Center, NY, United States

DWI has demonstrated potential in discriminating malignant from benign lesions. In this work we explored if DWI can improve PPV of contrast-enhanced MRI at 3.0 T. ADC values are significantly lower in malignant lesions compared to benign lesions yielding 86% sensitivity, 73% specificity, 86% PPV and 73% NPV with the optimal ADC threshold of 1.3x10 -3 mm 2 /s derived from ROC analysis. Higher mean ADC values were observed in DCIS lesions compared to invasive lesions, and low-risk benign compared with high risk benign lesions. DWI of lesion assessment improves the PPV of breast malignancy and can be used as an adjunct to MRI (PPV=34%) to avoid unnecessary benign biopsies.

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