Beyond Histopathologic Prognostication: Can DCE-MRI improve Breast Cancer Recurrence Risk Prediction?
Dania Daye 1 , Brad Keller 1 , Ahmed Ashraf 1 , Sarah Gavenonis 1 , Carolyn Mies 2 , Mark Rosen 1 , Michael Feldman 2 , and Despina Kontos 1
Department of Radiology, University of
Pennsylvania, Philadelphia, Pennsylvania, United States,
of Pathology and Laboratory Medicine, University of
Pennsylvania, Philadelphia, Pennsylvania, United States
Emerging studies suggest that imaging features could
complement standard pathologic variables in cancer
prognostic assessment. However, studies on the role of
DCE-MRI in improving breast cancer prognostication are
still limited. The goal of this study was to investigate
the complementary value of morphologic breast DCE-MRI
tumor characteristics as prognostic markers for breast
cancer recurrence risk assessment. DCE-MRI images were
retrospectively analyzed from 57 women with breast
cancer. Oncotype DX score was used as a surrogate for
cancer recurrence. Our results suggest that DCE-MRI
could complement histopathologic factors in predicting
breast cancer recurrence risk and could potentially
improve breast cancer prognostication.
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