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Abstract #0709

Beyond Histopathologic Prognostication: Can DCE-MRI improve Breast Cancer Recurrence Risk Prediction?

Dania Daye 1 , Brad Keller 1 , Ahmed Ashraf 1 , Sarah Gavenonis 1 , Carolyn Mies 2 , Mark Rosen 1 , Michael Feldman 2 , and Despina Kontos 1

1 Department of Radiology, University of Pennsylvania, Philadelphia, Pennsylvania, United States, 2 Department of Pathology and Laboratory Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, United States

Emerging studies suggest that imaging features could complement standard pathologic variables in cancer prognostic assessment. However, studies on the role of DCE-MRI in improving breast cancer prognostication are still limited. The goal of this study was to investigate the complementary value of morphologic breast DCE-MRI tumor characteristics as prognostic markers for breast cancer recurrence risk assessment. DCE-MRI images were retrospectively analyzed from 57 women with breast cancer. Oncotype DX score was used as a surrogate for cancer recurrence. Our results suggest that DCE-MRI could complement histopathologic factors in predicting breast cancer recurrence risk and could potentially improve breast cancer prognostication.

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