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Abstract #0702

Spatiotemporal Encoding Diffusion Weighted Imaging of the Breast: Comparison with SE-EPI-based methodology

Eddy Solomon 1 , Noam Nissan 1,2 , Amir Seginer 1 , Edna Furman-Haran 3 , Myra Shapiro-Feinberg 4 , Hadassa Degani 2 , and Lucio Frydman 1

1 Chemical Physics, Weizmann Institute of Science, Rehovot, Israel, 2 Biological Regulation, Weizmann Institute of Science, Rehovot, Israel, 3 Biological Services, Weizmann Institute of Science, Rehovot, Israel, 4 Radiology, Meir Hospital, Kfar Saba, Israel

A recently proposed MRI methodology, SPatio-temporal ENcoding (SPEN), was employed to quantify apparent diffusion coefficients in breast. SPEN is highly robust in terms of overcoming B0-inhomogeneities and heterogeneous chemical shift environments, and hence could present advantages in these challenging studies. Diffusion SPEN measurements were carried out at 3T and included healthy female volunteers and patients with biopsy-confirmed breast cancer. Substantial advantages in terms of both anatomical image qualities and diffusional information vis--vis EPI were observed, confirming SPENs ability to yield reliable ADC values and reveal a reduction of ADC in cancerous tissues.

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