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Abstract #0685

MRI guidance of Doxorubicin release from liposomes stimulated by pulsed low intensity non-focused Ultrasound in an experimental tumor model

Silvia Rizzitelli 1 , Pierangela Giustetto 1,2 , Juan Carlos Cutrin 1,3 , Marta Ruzza 1 , Cinzia Boffa 1 , Daniela Delli Castelli 1 , Valeria Menchise 4 , Filippo Molinari 5 , Silvio Aime 1,2 , and Enzo Terreno 1,2

1 Department of Molecular Biotechnology and Health Sciences, Molecular Imaging Center, University of Torino, Torino, Italy, 2 Center for Preclinical Imaging, University of Torino, Colleretto Giacosa, Torino, Italy, 3 (UBA-CONICET), ININCA, Buenos Aires, Argentina, 4 Institute for Biostructures and Bioimages (CNR) c/o Molecular Biotechnology Center, University of Torino, Torino, Italy, 5 Biolab, Department of Electronics and Telecommunications, Politecnico di Torino, Torino, Italy

Doxorubicin is one of the most effective antitumoral drugs, which is clinically administered in liposomal form to improve the therapeutic index and reduce side effects. Since liposomes are not able to deeply diffuse in the tumor, several methods to promote the release of the drug at the target site have been proposed. In this contribution, we used pulsed low-intensity non-focused US (pLINFU) as physical trigger to stimulate a mechanic release of the drug from stealth liposomes. The co-encapsulation of the MRI agent Gadoteridol provided a non invasive and efficient MRI guidance to monitor the drug release.

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